PO-0631: Molecular subtypes of glioblastoma: immunohistochemical approach and clinical correlations
نویسندگان
چکیده
منابع مشابه
Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications
The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own ...
متن کامل[Molecular subtypes of breast cancer: prognostic implications and clinical and immunohistochemical characteristics].
BACKGROUND Breast carcinomas are a heterogeneous group of tumours, in both their clinical behavior and their prognosis. The aim of this article is to classify breast carcinomas according to molecular subtypes by means of immunohistochemical markers and to analyse the clinicopathological and immunohistochemical characteristics and the patterns of survival and relapse of the different subtypes. ...
متن کاملMarked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.
Glioblastoma is classified into two subtypes on the basis of clinical history: "primary glioblastoma" arising de novo without detectable antecedent disease and "secondary glioblastoma" evolving from a low-grade astrocytoma. Despite their distinctive clinical courses, they arrive at an indistinguishable clinical and pathologic end point highlighted by widespread invasion and resistance to therap...
متن کاملMolecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma
BACKGROUND Gliomas are the most common primary malignant brain tumors in adults with great heterogeneity in histopathology and clinical course. The intent was to evaluate the relevance of known glioblastoma (GBM) expression and methylation based subtypes to grade II and III gliomas (ie. lower grade gliomas). METHODS Gene expression array, single nucleotide polymorphism (SNP) array and clinica...
متن کاملClinical and molecular characteristics of congenital glioblastoma.
Congenital glioblastoma (cGBM) is an uncommon tumor of infancy with a reported variable but often poor cure rate, even with intensive therapy. Five patients with cGBMs, arising de novo and not in familial tumor predisposition kindreds, were studied for histological and biological features, using Affymetrix microarray. Tumors were large, often associated with hemorrhage, extended into the thalam...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2017
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(17)31068-x